| Titre : | Evaluation of secular trends in CD4+lymphocyte loss among human immunodeficiency virus type 1 (HIV-1) - infected men with known dates of seroconversion. (1995) |
| Auteurs : | T.R. O'BRIEN ; Chen BAIBAI ; Roger Detels ; D.R. HOOVER ; L.A. KINGSLEY ; J. PHAIR ; P.S. ROSENBERG ; A.J. SAAH ; Us dep health human serv. National cancer inst. Epidemiology biostatistics program. Rockville MD. USA |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 142, n° 6, 1995) |
| Pagination : | 636-642 |
| Langues: | Anglais |
| Mots-clés : | Virose ; Infection ; Virus ; Lymphocyte ; Séropositivité ; Epidémiologie ; Homme ; Homosexualité ; Bisexualité ; Maladie autoimmune ; Sida |
| Résumé : | [BDSP. Notice produite par INIST N5cR0xrf. Diffusion soumise à autorisation]. The rate at which immunodeficiency develops in untreated human immunodeficiency virus type 1 (HIV-1) - infected persons might be increasing or decreasing over time because of viral evolution or other factors. Beginning in 1984, Multicenter AIDS Cohort Study investigators recruited HIV-1-seronegative homosexual/bisexual men from four US metropolitan areas and examined them semiannually for HIV-1 seroconversion. To assess possible secular changes in the natural history of HIV-1 infection, the authors examined CD4+lymphocyte data from 354 men who seroconverted between 1984 and 1991. To control for measurement differences among centers and over time, the authors adjusted CD4+lymphocyte values to those of persistently seronegative participants. CD4+lymphocyte percentage measurements at the first seropositive visit formed a U-shaped pattern, with the lowest values observed in 1988 and 1989. The authors observed no consistent secular pattern of CD4+percentages at later visit dates, except that mean CD4+percentages were consistently lowest in men who seroconverted in 1988. In a proportional hazards model, the time to the adjusted CD4+lymphocyte count of<500 cells/mm3 was not associated with the secular time of seroconversion (relative hazard=1.05,95% confidence interval 0.97-1.13). The authors'data do not suggest a major change in the natural history of HIV-1 infection in this population. Am J Epidemiol 1995 ; 142 : 636-42. |
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