| Titre : | CD4+T-cell number at the time of acquired immunodeficiency syndrome. (1995) |
| Auteurs : | J.M.G. TAYLOR ; J.V. GIORGI ; J.P. SY ; B. VISSCHER ; Univ California. Dep biostatistics. Los Angeles CA. USA |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 141, n° 7, 1995) |
| Pagination : | 645-651 |
| Langues: | Anglais |
| Mots-clés : | Virose ; Infection ; Survie ; Homme ; Epidémiologie ; Maladie autoimmune ; Sida |
| Résumé : | [BDSP. Notice produite par INIST FejR0xhZ. Diffusion soumise à autorisation]. In this article, the authors adapt and extend the methodology of Phillips (Phillips et al. J Acquir Immune Defic Syndr 1992 ; 5 : 148-52) to estimate the distribution of CD4+T-cell number at the time of acquired immunodeficiency syndrome (AIDS) and to estimate the correlation between CD4+T-cell number at AIDS and CD4+T-cell number prior to human immunodeficiency virus infection. Using data from the Los Angeles portion of the Multicenter AIDS Cohort Study, the authors find that the median CD4+T-cell count at the time of AIDS is 67 cells/mm3 with a 95% confidence interval of 58-84. The 5th and 95th percentiles of the distribution are 8 and 284, respectively. The authors estimate the correlation between the CD4+T-cell number at the time of AIDS and the CD4+T-cell number prior to human immunodeficiency virus infection to be 0.71 with a 95% confidence interval of 0.21-0.94. This very high correlation is suggestive of biologic hypotheses concerning possible control of the circulating CD4+T-cell number. The high correlation can also be useful in determining when to start prophylactic treatment. |
Service Documentation EHESP
Me connecter
PORTAIL DOCUMENTAIRE
École des hautes études en santé publique
Catalogue
Multi-bases
Accueil
Sélection de la langue
Adresse
Service Documentation EHESPBibliothèque Rennes Avenue du Professeur Léon Bernard – CS 74312 – 35043 Rennes Cedex Bibliothèque MSSH Paris 20 avenue George Sand - 93210 La Plaine Saint-Denis
France
Bibliothèque Rennes : 02 99 02 29 50 Bibliothèque MSSH Paris : 02 99 02 24 50
contact