| Titre : | Are US populations appropriate for trials of human immunodeficiency virus vaccine ? The HIVNET Vaccine Preparedness Study. (2001) |
| Auteurs : | George-Riii SEAGE ; Susan-P BUCHBINDER ; Connie CELUM ; Michael Gross ; Sarah-E HOLTE ; Franklyn-N JUDSON ; Beryl-A KOBLIN ; Michael MARMOR ; Kenneth-H MAYER ; David MCKIRNAN ; David METZGER ; Steven SELF ; A.M.Y. SHEON ; Cladd STEVENS ; George WOODY ; Abt Associates Inc. Cambridge. MA. USA ; Department of Biostatistics. University of Washington. Seattle. WA. USA ; Statistical Center for Hiv. Aids Research and Prevention Scharp Fred Hutchinson Cancer Research Center. Seattle. WA. USA ; University of Pennsylvania. Va Center for Studies of Addiction. Philadelphia. PA. USA |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 153, n° 7, 2001) |
| Pagination : | 619-627 |
| Langues: | Anglais |
| Mots-clés : | Sida ; Virose ; Infection ; Toxicomane ; Homme ; Epidémiologie ; Etats Unis ; Amérique ; Prévention santé ; Vaccination ; Essai préventif ; Essai thérapeutique ; Efficacité ; Incidence ; Examen sérologique ; Anticorps ; Comportement sexuel ; Sexe ; Homosexualité ; Toxicomanie ; Immunopathologie ; Amérique du Nord ; Recrutement |
| Résumé : | [BDSP. Notice produite par INIST tF1mNR0x. Diffusion soumise à autorisation]. Questions exist about whether testing of preventive human immunodeficiency virus (HIV) - 1 vaccines, which will require rapid recruitment and retention of cohorts with high HIV-1 seroincidence, is feasible in the United States. A prospective cohort study was conducted in 1995-1997 among 4,892 persons at high risk for HIV infection in nine US cities. At 18 months, with an 88% retention rate, 90 incident HIV-1 infections were observed (1.31/100 person-years (PY), 95% confidence interval (Cl) : 1.06,1.61). HIV-1 seroincidence rates varied significantly by baseline eligibility criteria-1.55/100 PY among men who had sex with men, 0.38/100 PY among male intravenous drug users, 1.24/100 PY among female intravenous drug users, and 1.13/100 PY among women at heterosexual risk-and by enrollment site, from 0.48/100 PY to 2.18/100 PY. HIV-1 incidence was highest among those men who had sex with men who reported unprotected anal intercourse (2.01/100 PY, 95% CI : 1.54,2.63), participants who were definitely willing to enroll in an HIV vaccine trial (1.96/100 PY, 95% Cl : 1.41,2.73), and women who used crack cocaine (1.62/100 PY, 95% CI : 0.92,2.85). Therefore, cohorts with HIV-1 seroincidence rates appropriate for HIV-1 vaccine trials can be recruited, enrolled, and retained. |
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