| Titre : | Geographical distribution of variant Creutzfeldt-Jakob disease in Great Britain, 1994-2000. (2001) |
| Auteurs : | Simon COUSENS ; D. EVERINGTON ; R.S.G. KNIGHT ; J. MACKENZIE ; M.A. MACLEOD ; P.G. Smith ; E.A.B. Smith-Bathgate ; G. STEWART ; H. WARD ; R.G. WILL ; M. ZEIDLER ; Department of Infectious and Tropical Diseases. London School of Hygiene and Tropical Medicine. London. GBR ; National Cjd Surveillance Unit. Western General Hospital. Edinburgh. GBR |
| Type de document : | Article |
| Dans : | Lancet (The) (vol. 357, n° 9261, 2001) |
| Pagination : | 1002-1007 |
| Langues: | Anglais |
| Mots-clés : | Infection ; Incidence ; Epidémiologie ; Royaume Uni ; Europe ; Adulte ; Homme ; Prion ; Système nerveux [pathologie] |
| Résumé : | [BDSP. Notice produite par INIST R0xgS35X. Diffusion soumise à autorisation]. Background Geographical variation in the distribution of variant Creutzfeldt-Jakob disease (vCJD) might indicate the transmission route of the infectious agent to man. We investigated whether regional incidences of vCJD were correlated with regional dietary data. Methods The National CJD Surveillance Unit prospectively identified 84 people with vCJD up to Nov 10,2000, in Great Britain. Their lifetime residential histories were obtained by interviews with a close relative. Cumulative incidences of vCJD by standard region were calculated. Grid references for places of residence in 1991 were identified and evidence of geographical clusters were sought. Data on diet in the 1980s were analysed for regional correlations with vCJD incidence. The socioeconomic status of the places of residence of people with vCJD was compared with that of the general population. Findings vCJD incidence was higher in the north of Great Britain than the south. The rate ratio (north vs south) was 1.94 (95% Cl 1.27-2.98). The mean Carstairs'deprivation score for areas of residence of people with vCJD was - 0.09 (-0.73 to 0.55), which is close to the national average of zero. Regional rates of vCJD were correlated with consumption of other meat or meat products as classified and recorded by the Household Food Consumption and Expenditure Survey (r=0.72), but not with data from the Dietary and Nutritional Survey of British Adults. Five people with vCJD in Leicestershire formed a cluster (p=0.004). (...) |
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