| Titre : | Relation of alleles of the sodium-potassium adenosine triphosphatase alpha2 gene with blood pressure and lead exposure. (2001) |
| Auteurs : | Barbara-S GLENN ; Joseph BRESSLER ; Brian-S SCHWARTZ ; Walter-F STEWART ; Department of Epidemiology. School of Hygiene and Public Health. Johns Hopkins University. Baltimore. MD. USA ; Department of Neurology. Kennedy Krieger Research Institute. Johns Hopkins Medical Institutions. Baltimore. MD. USA |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 153, n° 6, 2001) |
| Pagination : | 537-545 |
| Langues: | Anglais |
| Mots-clés : | Hypertension artérielle ; Homme ; Epidémiologie ; Etats Unis ; Amérique ; Facteur risque ; Plomb ; Enzyme ; Appareil circulatoire [pathologie] ; Médecine travail ; Exposition professionnelle ; Amérique du Nord |
| Résumé : | [BDSP. Notice produite par INIST R0x63DaH. Diffusion soumise à autorisation]. Lead is associated with elevated blood pressure, although the mechanism of action is unknown. Genetic differences in sodium-potassium adenosine triphosphatase (Na+-K+ATPase) could explain some of the variation in the strength of the blood pressure-blood lead relation that has been observed in previous studies. In 1996-1997, the authors studied the association of blood pressure, hypertension prevalence, and polymorphisms in the gene for the alpha2 subunit of Na+-K+ATPase (ATP1A2) among 220 former organolead manufacturing workers from New Jersey. Subjects were genotyped for a restriction fragment length polymorphism (RFLP) on the ATP1A2 gene. The association between blood lead and blood pressure was stronger among persons who were homozygous for the variant allele. Genotype was also associated with hypertension (adjusted odds ratio=7.7 ; 95% confidence interval : 1.9,31.4). Finally, the variant allele was 1.8 times more common among African Americans than among Caucasians. The RFLP may indicate susceptibility to the effect of lead on blood pressure. Moreover, the a2 gene (or a closely linked gene) may contribute to the pathophysiology of hypertension. However, because the number of subjects (especially African Americans) with the susceptible genotype in this study was small, these observations should be considered preliminary. |
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