| Titre : | Lowered weight gain during pregnancy and risk of neural tube defects among offspring : Fetal origins of health and disease. (2001) |
| Auteurs : | Gary-M SHAW ; Suzan-L CARMICHAEL ; Donna-M SCHAFFER ; Steve Selvin ; Karen TODOROFF ; March of Dimes Birth Defects Foundation. California Birth Defects Monitoring Program. Emeryville. CA. USA |
| Type de document : | Article |
| Dans : | International journal of epidemiology (vol. 30, n° 1, 2001) |
| Pagination : | 60-65 |
| Langues: | Anglais |
| Mots-clés : | Régime alimentaire ; Grossesse ; Mère ; Prise poids ; Anencéphalie ; Spina bifida ; Epidémiologie ; Facteur risque ; Nouveau né ; Homme ; Alimentation ; Système nerveux [pathologie] ; Maladie congénitale ; Malformation ; Système ostéoarticulaire [pathologie] ; Rachis [pathologie] |
| Résumé : | [BDSP. Notice produite par INIST rkKpOR0x. Diffusion soumise à autorisation]. Background Maternal nutritional factors have been implicated in the complex aetiology of neural tube defects (NTD). We investigated whether the amount of weight a woman gained during pregnancy was associated with her risk of delivering an infant with an NTD. Methods We conducted a population-based case-control study within the cohort of 708 129 live births and fetal deaths occurring in selected California counties in 1989-1991. Face-to-face interviews were conducted with mothers of 538 (88% of eligible) NTD cases (including those electively terminated, stillborn, or liveborn) and with mothers of 539 (88%) non-malformed liveborn controls within an average of 5 months from the term delivery date. Respondent-reported weight gain during pregnancy (kg) was analysed. Risks of infants having NTD were estimated among women who gained<10kg compared to those who gained >= 10kg during >= 38 week gestations. Results Compared to women who gained >= 10kg, an increased risk for NTD offspring was observed among women who gained<10kg (odds ratio [OR]=3.2,95% CI : 2.3-4.6). The OR was 5.0 (95% CI : 2.6-9.7) among those women who gained<5 kg during pregnancy. (...) |
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