| Titre : | Association between premature mortality and hypopituitarism. (2001) |
| Auteurs : | J.W. TOMLINSON ; A.S. Bates ; R.N. CLAYTON ; R.K. HILLS ; N. HOLDEN ; M.C. SHEPPARD ; P.M. STEWART ; K. WHEATLEY ; Division of Medical Sciences. Queen Elizabeth Hospital. University of Birmingham. Birmingham. GBR ; University of Birmingham Clinical Trials Unit. Birmingham. USA ; West Midlands Prospective Hypopituitary Study Group. GBR |
| Type de document : | Article |
| Dans : | Lancet (The) (vol. 357, n° 9254, 2001) |
| Pagination : | 425-431 |
| Langues: | Anglais |
| Mots-clés : | Mortalité ; Facteur ; Epidémiologie ; Facteur risque ; Royaume Uni ; Europe ; Adulte ; Homme ; Enfant ; Glande endocrine [pathologie] ; Hypophyse [pathologie] |
| Résumé : | [BDSP. Notice produite par INIST tR0xzJTI. Diffusion soumise à autorisation]. Background Four retrospective studies have reported premature mortality in patients with hypopituitarism with standard mortality ratios (SMRs) varying between 1.20 and 2.17. Patients with hypopituitarism have complex endocrine deficiencies, and the mechanisms underpinning any excess mortality are unknown. Furthermore, the suggestion has emerged that endogenous growth-hormone deficiency might account for any excess mortality. We aimed to clarify these issues by doing a large prospective study of total and specific-cause mortality in patients with hypopituitarism. Methods We followed up 1014 UK patients (514 men, 500 women) with hypopituitarism from January, 1992, to January, 2000. 573 (57%) patients had non-functioning adenomas, 118 (12%) craniopharyngiomas, and 93 (9%) prolactinomas. SMRs were calculated as the ratio of observed deaths to the number of deaths in an age-matched and sex-matched UK population. Findings The number of observed deaths was 181 compared with the 96.7 expected (SMR 1.87 [99% Cl 1.62-2.16], p<0.0001). Univariate analysis indicated that mortality was higher in women (2.29 [1.86-2.82]) than men (1.57 [1.28-1.93], p=0.002), in younger patients, in patients with an underlying diagnosis of craniopharyngioma (9.28 [5.84-14.75] vs 1.61 [1.30-1.99], p<0.0001), and in the 353 patients treated with radiotherapy (2.32 [1.71-3.14] vs 1.66 [1.30-2.13], p=0.004). Excess mortality was attributed to cardiovascular (1.82 [1.30-2.54], p<0.0001), respiratory (2. (...) |
Service Documentation EHESP
Me connecter
PORTAIL DOCUMENTAIRE
École des hautes études en santé publique
Catalogue
Multi-bases
Accueil
Sélection de la langue
Adresse
Service Documentation EHESPBibliothèque Rennes Avenue du Professeur Léon Bernard – CS 74312 – 35043 Rennes Cedex Bibliothèque MSSH Paris 20 avenue George Sand - 93210 La Plaine Saint-Denis
France
Bibliothèque Rennes : 02 99 02 29 50 Bibliothèque MSSH Paris : 02 99 02 24 50
contact