Résumé :
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[BDSP. Notice produite par INIST QR0xaWs2. Diffusion soumise à autorisation]. Erionite present in stones used to build the villages of Karain and Tuzkoy, Turkey, mined from nearby caves, Is purported to cause mesothelioma In half of the villagers. We constructed genetic epidemiology maps to test whether some villagers were genetically predisposed to mesothelloma. Analysis of a six-generation extended pedigree of 526 Individuals showed that mesothelloma was genetically transmitted, probably In an autosomal dominant way. This finding should lead to preventive strategies to lower the Incidence of mesothelioma In future generations, and close monitoring of high-risk Individuals might allow early detection and cure.
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