Résumé :
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[BDSP. Notice produite par INIST q1cR0x1Y. Diffusion soumise à autorisation]. Objective-To discuss the merits of the patient follow up study design for the evaluation of some specific mass screening programmes. Design-Theoretical evaluation illustrated by two examples. Setting-Department of Public Health Erasmus University Rotterdam. Main results-The gold standard for evaluation of favourable effects of screening is the randomised controlled trial (RCT). Application of an RCT, however, is often not feasible, in which cases observational studies will have to be relied on. The case-control study design is generally considered to be second best. In some situations, however, a patient follow up study design may be applicable and may have some major advantages. The use of the patient follow up design for screening evaluation will often be very problematic or even unacceptable, particularly as far as screening for cancer is concerned. The most important objections are resulting from lead time bias, length bias, selection bias and over-treatment bias. For the evaluation of screening for congenital heart disease and congenital hip dislocation in Dutch child health care, however, these objections may relatively simply be overcome. Lead time bias will be of little importance, as the ages of onset of these disorders are fixed, namely at birth, and their ultimate outcomes may be expected within relatively short time. (...)
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