| Titre : | Cryptosporidium infection in Bedouin infants assessed by prospective evaluation of anticryptosporidial antibodies and stool examination. (2001) |
| Auteurs : | Guy ROBIN ; Ruhama AMBAR ; Dani COHEN ; R.O.N. DAGAN ; Richard-J DECKELBAUM ; Drora FRASER ; Sylvie LE BLANCQ ; Nadav ORR ; Tamar SELA ; Raphael SLEPON ; Army Health Branch Research Unit. Medical Corps. Israel Defence Force. ISR |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 153, n° 2, 2001) |
| Pagination : | 194-201 |
| Langues: | Anglais |
| Mots-clés : | Protozoaire ; Infection ; Examen sérologique ; Anticorps ; Nourrisson ; Homme ; Israël ; Asie ; Malnutrition ; Facteur risque ; Parasitose |
| Résumé : | [BDSP. Notice produite par INIST 7R0xZbCL. Diffusion soumise à autorisation]. An enzyme-linked immunosorbent assay system using oocyst lysate as antigen was used to detect serum-specific antibody responses to Cryptosporidium parvum between 1989 and 1994 in consecutive sera obtained at birth, and at the age of 6,12, and 23 months, from 52 infants living in a Bedouin town located in the south of Israel. The serologic tests revealed high levels of immunoglobulin G anti-Cryptosporidium at birth that dropped significantly by the age of 6 months and then rose continuously to a geometric mean titer of 481 at age 23 months. The serum immunoglobulin M Cryptosporidium antibodies rose continuously from nearly undetectable levels at birth to a geometric mean titer of 471 (157-fold increase) at age 23 months. All the subjects already showed at 6 months a significant rise in immunoglobulin M. A significant rise in immunoglobulin A titers was detected in 48% and 91% of subjects at 6 and 23 months, respectively. By monthly surveillance, microscopy using the modified Ziehl-Neelsen method and confirmed by indirect immunofluorescence assay detected Cryptosporidium antigens in only 11% at age 6 months and 48% at age 23 months. The extent of exposure to Cryptosporidium immediately after birth as detected by serology is much higher than that predicted by frequent prospective assessment of stool samples. |
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