| Titre : | Plasma 1,1-dichloro-2,2-bis (p-chlorophenyl) ethylene (DDE) levels and immune response. (2001) |
| Auteurs : | Marilyn-F VINE ; Lorraine BACKER ; Darrah DEGNAN ; Jane SCHROEDER ; Leonard STEIN ; Chui-Kit-j TSE ; Kristen WEIGLE ; Department of Epidemiology. University of North Carolina. Chapel Hill. NC. USA |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 153, n° 1, 2001) |
| Pagination : | 53-63 |
| Langues: | Anglais |
| Mots-clés : | Toxicologie ; Homme ; Epidémiologie ; Exposition ; Pesticide |
| Résumé : | [BDSP. Notice produite par INIST uIZD9R0x. Diffusion soumise à autorisation]. For determination of whether plasma 1,1-dichloro-2,2-bis (p-chlorophenyl)) ethylene (DDE) pesticide levels (<=1-32 ppb) are associated with immune suppression or DNA damage in lymphocytes, 302 individuals residing in Moore County, North Carolina, in 1994-1996 provided a blood specimen, underwent a skin test, and answered a questionnaire concerning factors affecting plasma organochlorine pesticide levels and the immune system. The blood specimens were analyzed for levels of plasma DDE (a metabolite of 1,1,1-trichloro-2,2-bis (p-chlorophenyl) ethane), numbers and types of blood cells, immunoglobulin levels, mitogen-induced lymphoproliferative activity, and lymphocyte micronuclei. When DDE levels were categorized as 1 or less, more than 1 to 2, more than 2 to 4.3, more than 4.3 to 7.6, and more than 7.6 ppb, individuals with higher plasma DDE levels had lowered mitogen-induced lymphoproliferative activity (concanavalin A, range : 74,218 dropping to 55,880 counts per minute, p=0.03) and modestly increased total lymphocytes (range : 2.0-2.3 x 103/mul, p=0.05) and immunoglobulin A levels (range : 210-252 mg/dl, p=0.04). There were no consistent differences in response to the skin tests by plasma DDE levels. Plasma DDE levels were not associated with a higher frequency of micronuclei. (...) |
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