| Titre : | Effect of maternal smoking and coffee consumption on the risk of having a recognized Down syndrome pregnancy. (2000) |
| Auteurs : | Claudine-P TORFS ; Roberta-E CHRISTIANSON ; California Birth Defects Monitoring Program. Oakland. CA. USA |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 152, n° 12, 2000) |
| Pagination : | 1185-1191 |
| Langues: | Anglais |
| Mots-clés : | Tabagisme passif ; Tabagisme ; Mère ; Consommation alimentaire ; Café ; Régime alimentaire ; Grossesse ; Epidémiologie ; Facteur risque ; Nouveau né ; Homme ; Etats Unis ; Amérique ; Alimentation ; Aberration chromosomique ; Maladie congénitale ; Amérique du Nord |
| Résumé : | [BDSP. Notice produite par INIST XTjgR0xl. Diffusion soumise à autorisation]. To evaluate the possible effects of maternal smoking and caffeine or coffee consumption on the occurrence of a recognized pregnancy with Down syndrome, the authors analyzed data from a case-control study of 997 liveborn infants or fetuses with Down syndrome ascertained in California from 1991 to 1993 and 1,007 liveborn controls without a birth defect. Interviews with mothers covered demographic information, pregnancy, and medical history, with detailed questions on the use of tobacco, alcohol, and caffeinated beverages. All analyses were age-adjusted. High alcohol consumption (>=4 drinks/week) in the first month of pregnancy was associated with reduced risk for a recognized Down syndrome conceptus (odds ratio (OR)=0.54 ; 95% confidence interval (CI) : 0.34,0.85). Maternal smoking during the periconceptional period was not associated with risk of recognized Down syndrome (OR=1.04 ; 95% Cl : 0.79,1.37), but maternal consumption of four or more cups of coffee per day was inversely associated (OR=0.63 ; 95% CI : 0.41,0.96). In multivariate analysis, a significant interaction between coffee drinking and smoking was observed. The inverse association remained only for nonsmoking mothers who drank four or more cups of coffee per day (OR=0.48 ; 95% CI : 0.28,0.82). These results suggest that among nonsmoking mothers, high coffee consumption is more likely to reduce the viability of a Down syndrome conceptus than that of a normal conceptus. |
Service Documentation EHESP
Me connecter
PORTAIL DOCUMENTAIRE
École des hautes études en santé publique
Catalogue
Multi-bases
Accueil
Sélection de la langue
Adresse
Service Documentation EHESPBibliothèque Rennes Avenue du Professeur Léon Bernard – CS 74312 – 35043 Rennes Cedex Bibliothèque MSSH Paris 20 avenue George Sand - 93210 La Plaine Saint-Denis
France
Bibliothèque Rennes : 02 99 02 29 50 Bibliothèque MSSH Paris : 02 99 02 24 50
contact