Résumé :
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[BDSP. Notice produite par INIST R0xPPuX8. Diffusion soumise à autorisation]. There is growing evidence that prenatal exposures may influence later breast cancer risk. This matched case-control study used linked New York State birth and tumor registry data to examine the association between birth characteristics and breast cancer risk among women aged 14-37 years. Cases were women diagnosed with breast cancer between 1978 and 1995 who were also born in New York after 1957 (n=484). For each case, selected controls were the next six liveborn females with the same maternal county of residence. The authors found a J-shaped association between birth weight and breast cancer risk, and very high birth weight (>4,500 g) was associated with the greatest elevation in risk (adjusted odds ratio (OR)=3.10,95% confidence interval (Cl) : 1.18,7.97). The association of maternal age with breast cancer risk was also J-shaped, with maternal age of more than 24 years showing a positive, linear association (adjusted OR=1.94,95% CI : 1.18,3.18 for maternal age >=35 vs. 20-24 years ; p for trend=0.02). In contrast, women born very preterm had a lower risk (adjusted OR=0.11,95% Cl : 0.02,0.79 for gestational age=37 weeks). These findings support a role for early life factors in the development of breast cancer in very young women.
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