| Titre : | Nitrosatable Drug Exposure During Early Pregnancy and Neural Tube Defects in Offspring : National Birth Defects Prevention Study. (2011) |
| Auteurs : | Jean-D BRENDER ; Mark-A CANFIELD ; John-S GRIESENBECK ; John-Cjr HUBER ; Katherine-E KELLEY ; Peter-H LANGLOIS ; . QI ZHENG ; Paul-A ROMITTI ; Joseph-R SHARKEY ; Mayura-U SHINDE ; Lucina Suarez ; Ann-M VUONG ; Martha-M WERLER ; Birth Defects Epidemiology and Surveillance Branch. Texas Department of State Health Services. Austin. TX. USA ; Department of Epidemiology and Biostatistics. School of Rural Public Health. Texas A & M Health Science Center. College Station. TX. USA |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 174, n° 11, 2011) |
| Pagination : | 1286-1295 |
| Langues: | Anglais |
| Mots-clés : | Anencéphalie ; Préparation magistrale ; Médicament ; Exposition ; Famille descendante ; Malformation ; Nouveau né ; Prévention santé ; Vitamine C ; Epidémiologie ; Homme ; Maladie congénitale ; Vitamine |
| Résumé : | [BDSP. Notice produite par INIST-CNRS F7FoR0xk. Diffusion soumise à autorisation]. Nitrosatable drugs, such as secondary or tertiary amines and amides, form N-nitroso compounds in the presence of nitrite. Various N-nitroso compounds have been associated with neural tube defects in animal models. Using data from the National Birth Defects Prevention Study, the authors examined nitrosatable drug exposure 1 month before and 1 month after conception in 1,223 case mothers with neural tube defect-affected pregnancies and 6,807 control mothers who delivered babies without major congenital anomalies from 1997 to 2005. Nitrite intakes were estimated from. mothers'responses to a food frequency questionnaire. After adjustment for maternal race/ethnicity, educational level, and folic acid supplementation, case women were more likely than were control women to have taken tertiary amines (odds ratio=1.60,95% confidence interval (CI) : 1.31,1.95). This association was strongest with anencephalic births (odds ratio=1.96,95% CI : 1.40,2.73) ; odds ratios associated with tertiary amines from the lowest tertile of nitrite intake to the highest tertile were 1.16 (95% CI : 0.59,2.29), 2.19 (95% CI : 1.25,3.86), and 2.51 (95% CI : 1.45,4.37), respectively. Odds ratios for anencephaly with nitrosatable drug exposure were reduced among women who also took daily vitamin supplements that contained vitamin C. Prenatal exposure to nitrosatable drugs may increase the risk of neural tube defects, especially in conjunction with a mother's higher dietary intake of nitrites, but vitamin C might modulate this association. |
Service Documentation EHESP
Me connecter
PORTAIL DOCUMENTAIRE
École des hautes études en santé publique
Catalogue
Multi-bases
Accueil
Sélection de la langue
Adresse
Service Documentation EHESPBibliothèque Rennes Avenue du Professeur Léon Bernard – CS 74312 – 35043 Rennes Cedex Bibliothèque MSSH Paris 20 avenue George Sand - 93210 La Plaine Saint-Denis
France
Bibliothèque Rennes : 02 99 02 29 50 Bibliothèque MSSH Paris : 02 99 02 24 50
contact