| Titre : | Body Size and Colorectal Cancer Risk After 16.3 Years of Follow-up : An Analysis From the Netherlands Cohort Study. (2011) |
| Auteurs : | Laura-Ae HUGHES ; ENGELAND (Manon-Van) : NLD. Department of Pathology. Grow School for Oncology and Developmental Biology. Maastricht University. Maastricht. ; GOLDBOHM (Ralexandra) : NLD. Department of Prevention and Health. Tno Quality of Life. Leiden. ; Colinda-Cjm SIMONS ; Piet-A VAN DEN BRANDT ; Matty-P WEIJENBERG |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 174, n° 10, 2011) |
| Pagination : | 1127-1139 |
| Langues: | Anglais |
| Mots-clés : | Taille corporelle ; Facteur risque ; Risque ; Rectum ; Epidémiologie ; Europe ; Cancer ; Côlon |
| Résumé : | [BDSP. Notice produite par INIST-CNRS R0x8slqr. Diffusion soumise à autorisation]. A large body size may differentially influence risk of colorectal cancer (CRC) by anatomic location. The Netherlands Cohort Study includes 120,852 men and women aged 55-69 years who self-reported weight, height, and trouser/skirt size at baseline (1986), as well as weight at age 20 years. Derived variables included body mass index (BMI ; weight (kg)/height (m) 2), BMI at age 20 years, and BMI change. After 16.3 years of follow-up (1986-2002), 2,316 CRC cases were available for case-cohort analysis. In men, the highest risk estimates were observed for body fat (per 5-unit increase in BMI, hazard ratio (HR)=1.25,95% confidence interval (CI) : 1.05,1.46 ; for highest quintile of trouser size vs. lowest, HR=1.63,95% CI : 1.17,2.29 (P-trend=0.02)) and appeared more closely associated with distal colon tumors (for BMI (5-unit increase), HR=1.42,95% CI : 1.13,1.79 ; for highest quintile of trouser size, HR=2.56,95% CI : 1.55,4.24 (P-trend<0.01)) than with proximal colon or rectal tumors. In women, body fat was not associated with CRC risk unless it was considered simultaneously with physical activity ; a large trouser/skirt size and a low level of physical activity increased risk for all subtypes. Height was associated with risk of CRC, especially distal colon tumors (highest quintile vs. lowest : HR=1.53,95% CI : 1.03,2.27 ; P-trend=0.05), in women only. |
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