| Titre : | Risk factors for uterine leiomyoma : A practice-based case-control study. I. African-American heritage, reproductive history, body size, and smoking. (2001) |
| Auteurs : | Eduardo FAERSTEIN ; Neil ROSENSHEIN ; Moyses Szklo |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 153, n° 1, 2001) |
| Pagination : | 1-10 |
| Langues: | Anglais |
| Mots-clés : | Utérus ; Homme ; Femme ; Epidémiologie ; Etats Unis ; Amérique ; Facteur risque ; Ethnie ; Reproduction ; Tabagisme ; Tumeur bénigne ; Utérus [pathologie] ; Amérique du Nord |
| Résumé : | [BDSP. Notice produite par INIST 2R1gUR0x. Diffusion soumise à autorisation]. The authors conducted a case-control study among premenopausal women in the Baltimore, Maryland, area to examine the associations of uterine leiomyoma with ethnicity and hormone-related characteristics. Cases of uterine leiomyoma (n=318) were surgically or sonographically first confirmed between January 1990 and June 1993. A total of 394 controls were selected from women who were visiting their gynecologist for a routine checkup. Data were collected through telephone interviews and abstraction of medical records ; 77.8% of eligible cases and 78.0% of eligible controls were interviewed. Positive adjusted associations were observed between risk of uterine leiomyoma and self-described African-American ethnicity (vs. Whites : odds ratio (OR)=9.4 ; 95% confidence interval (CI) : 5.7,15.7), early menarche (<11 years vs.>13 years : OR=2.4 ; 95% CI : 1.1,5.6), and high body mass index (upper quartile vs. lower quartile : OR=2.3 ; 95% CI : 1.4,3.8). Inverse associations were observed with use of oral contraceptives (current use vs. never use : OR=0.2,95% Cl : 0.1,0.6) and duration of smoking (>19 years vs. never : OR=0.6 ; 95% CI : 0.4,1.1). Younger ages at infertility diagnosis and at first and last childbirth were more common among cases ; however, analyses of data on tumor location suggested that these associations represent predominantly consequences of uterine leiomyoma. (...) |
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